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Studies show that up to 40% of weight lost on GLP-1 medications can be lean mass if protein intake is inadequate
Increased activity of the endocannabinoid system has been associated with gut dysbiosis related to obesity in mice models
Semaglutide carries the most extensive clinical trial history of the three, including the previously cited 68-week trial reporting average weight reductions exceeding 14%, which makes it a common reference point for metabolic and receptor-signaling studies
The most common concern involves gastrointestinal adverse effects, which are already the most frequently reported side effects of GLP-1 receptor agonists
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