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doi: 10.1146/annurev.pharmtox.43.100901.135828 121

In this review, we also aim to elucidate the effects of metformin on adolescence, pregnancy, and the long-term health of patients with PCOS, so as to meet the diverse clinical treatment requirements of individuals with PCOS and to improve the fertility of females in their reproductive years

Similarly, tissue levels of inflammatory cytokines were significantly decreased

In vitro and in vivo studies may suggest or provide a useful degree of efficacy, but do not provide a complete representation of the clinical heterogeneity present in human disease