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Among explanations for the absence of effect of long-term L-arginine administration in some clinical trials, oxidative depletion of BH 4 can result in eNOS uncoupling even with sufficient L-arginine supply (Xiong et al., 2014

And if you're dealing with diarrhea or vomiting on top of everything else, hydration becomes extra importantaim for at least eight glasses of water daily, because dehydration is basically an energy vampire