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The result is a faster transition through each healing phase and higher-quality repair, particularly for tissues with poor native blood supply like tendons, ligaments, and cartilage

Since immune cell trafficking into the CNS is tightly regulated by the blood brain barrier which selectively only allows entry of immune cell subsets required for immune surveillance (80), it remains unknown if CAR-T would efficiently reach senescent cells in the brain parenchyma

Reduced expression of inflammatory cytokines TNF-, IL-6 has been reported in multiple preclinical models

A significant portion is excreted within the first 8 hours