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High prices of medicines like semaglutide and tirzepatide are limiting access to these medicines, the WHO statement added, saying that encouraging generic drugmakers to produce the product would also help when patents begin to expire on the drugs next year

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Additionally, defective insulin signaling contributes to neuronal energy deficits by decreasing glucose uptake and reducing the expression and function of glucose transporters GLUT3 and GLUT4 in the central nervous system (Schulingkamp et al., 2000)