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According to the medicines' Summary of Product Characteristics (SmPCs), no dose adjustment is generally required for patients with mild to moderate hepatic impairment
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The Wegovy pill and Rybelsus are currently available in oral form, with orforglipron (Eli Lilly) under FDA review
Further, unlike GLP-1, GIP increases triglyceride storage in white adipose tissue, does not delay gastric emptying, and may impact bone remodeling--functions that were thought to limit GIPs utility in T2D and weight loss
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