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One of the possible reasons that anaemia is much less prominent in B12 deficiency than lets say 30 years ago, is that many countries have started mandatory fortification of food with folate
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In the context of these co-crystal structures, Compound 24 consistently engaged key conserved hydrophobic residues (M336, L388, F392, and F424) and formed hydrogen bonds with Q421, while additional interactions with H223, Y222, I371, H373, I428, P408, L409, M389, and V417 contributed to specificity (Figures 9AE)
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