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African females are 3%, and the carrier rate is around 20%
Genetic ablation of CB1R specifically in macrophages or in beta cells prevents islet inflammation in diet-induced obesity [7, 10]
However, the duration of the experiment was just 8 weeks, which made it impossible to determine the long-term consequences of these effects in terms of permanent reproductive dysfunction or recovery after a longer period of time
The dosage is gradually increased over several weeks to minimize side effects and optimize effectiveness
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