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Finally, while the Framingham Risk Scores are a standard for estimating CVD events, like most risk scores, they are not as accurate as capturing actual CVD events as would be the case in a true cardiovascular outcomes clinical trial

Phase I and II clinical trials conducted have shown improved cognitive and motor function with different drugs from GLP-1RA group although the small sized and limited duration of trials have not provided a conclusive result to influence the practice, although with further advancement in ongoing trials effects observed may be noteworthy for intervention in future practice (119)

Patients with significant comorbidities, those taking multiple medications, or those with complex medical histories may be underrepresented in clinical trials

Schedule exercise when symptoms are least bothersome and ensure adequate pre-exercise nutrition to maintain consistency