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[8] [20] Beyond nausea, patients commonly experience a constellation of gastrointestinal symptoms including: Vomiting (reported in 24% of semaglutide users) Diarrhea (affecting 30% of patients) Constipation (occurring in 24% of users) Abdominal pain or discomfort (experienced by 20% of patients) Bloating and excessive gas Acid reflux or heartburn Decreased appetite (which, while therapeutic, can feel uncomfortable) The severity of these symptoms typically ranges from mild to moderate, and most patients do not discontinue treatment due to nausea alone
In the presence of a hyperinsulinemic response, which occurred in 39 out of our 45 PCOS patients (86.6%), the mix of complementary substances used was able to modulate the metabolic profile and decrease the excess of insulin, as well as improve the HOMA index and lipid concentrations during the entire 6 months of treatment
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