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However, high supplemental doses of niacin may cause niacin flush, nausea, vomiting, stomach irritation and liver damage

Consistent with the data in mice, the activation of circulating neutrophils as an indicator for the activation status of hepatic neutrophils showed no neutrophil activation during the injury phase but substantial activation (ROS, phagocytosis) selectively during the recovery phase [98]

This increase in intestinal permeability was also observed in rats and Guinea pigs exposed to 5% -PGN in drinking water for 5 months and 6 weeks, respectively (Delahunty, Recher, and Hollander 1987 Delahunty, T., L

In addition, three eligible reports were identified through other sources (reference list screening/citation searching) and were included