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Because DSIP is a small peptide that acts on the central nervous system and is degraded relatively quickly in plasma (for example, one study reported a half-life of ~78 minutes in human plasma)
By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis and fat oxidation [3]
2023 Nov 1;2023:9781805) 1 Centro universitrio Baro de Mau, CBM, Ribeiro Preto, So Paulo, Brasil
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