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Although the degradation of glutathione contributes to the cysteine pool, the resulting levels are not sufficient for normal metabolism upon cystine scarcity
Tumor-associated macrophages and fibroblasts may secrete IGF to activate IGF-IR in cancer cells thereby promoting chemoresistance and radioresistance [187, 188]
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This outcome is important because a large quantity of studies published on toxicity of AFB1 for the animal and human bodies addressed oxidative stress and inflammatory responses as health consequences of this carcinogenic mycotoxin
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