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In addressing the bioavailability issue, several novel delivery systems incorporating natural herbs or compounds have been developed ( Among the botanical drugs and polyherbal formulations reviewed, only Curcuma longa ( , Camellia sinensis ( Curcuma longa were limited without the presence of a negative control group, while a systematic review of randomized clinical trials conducted on GZFLW revealed that the trials have a high risk of bias, with no description of the allocation concealment of the participants
For dietary deficiency in the absence of malabsorption, oral cyanocobalamin supplementation (50150 micrograms daily) may suffice, though compliance and absorption must be monitored
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