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Consequently, lower citrate ( m + 2)/PA ( m + 16) and malate ( m + 2)/PA ( m + 16) ratios were detected in shGDH1 cells (Supplementary Fig
Song Y et al
While their immunomodulatory effects, including macrophage repolarization, contribute to their broader anti-tumor mechanism, future studies are needed to elucidate the specific pathways involved and to optimize strategies for combining OVs with macrophage-repolarizing therapies like CSF1R inhibitors to improve clinical outcomes (206)
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