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[91] Macrophages during SLE fail to mature their lysosomes and as a result have impaired degradation of internalized apoptotic debris, which results in chronic activation of Toll-like receptors and permeabilization of the phagolysosomal membrane, allowing activation of cytosolic sensors

22 It has been suggested that cinchonine is less toxic than other quinine-related compounds

Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma

The dynamic regulation by protein kinases and protein phosphatases further establishes phosphorylation as a crucial regulatory mechanism in ferroptosis