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NAC has been tried in numerous chronic diseases with similarly disappointing results, including cystic fibrosis protection against contrast-induced nephropathy and thrombosis [14]
In the phase 1/2 trial, alpelisib (a PI3K inhibitor) plus nab-paclitaxel was well tolerated and showed encouraging efficacy, especially in patients with metastatic PIK3CA -mutated HER2 breast cancer, despite that TNBC has lower efficacy than HR+/HER2 patients
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