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The demand for GLP-1s has outpaced supply for years, leading to intermittent shortages that leave patients scrambling
Hypoglycaemia: Whilst the risk is lower than with insulin or sulphonylureas, low blood glucose can occur, particularly in individuals also taking other glucose-lowering agents
By overcoming the low oral bioavailability challenges of peptide GLP-1 RAs, Orforglipron represents a disruptive innovation that could reshape the treatment paradigm for type 2 diabetes
Of note, there are two types of AD, sporadic AD is account for 90% of AD, and familial AD is account for 10% of AD
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