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Reduced SAM-to-SAH Ratio A low ratio suggests less effective methylation potential even when a single SAM value appears adequate
This is exemplified by experimental models showing that selective ablation or stimulation of Agouti-related peptide (AgRP)/NPY/GABA neurons in the basomedial hypothalamus leads to either starvation or hyperphagia with subsequent obesity, respectively (114, 115)
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