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I., Kim, W

Most combination data comes from the CagriSema program (cagrilintide + GLP1, not GLP3)

126 YuanB.ZhaoX.ShenJ.ChenS.HuangH.ZhouX.et al (2022)

Immune effects are restorative, not overstimulating: It rebalances T-cell ratios, upregulates IL-2 in aged tissues, and improves neuroimmune integration, suggesting a targeted recalibration of immune tone rather than indiscriminate boosting. It restores circadian and hormonal rhythms: By stimulating melatonin synthesis, protecting pineal structure, and re-entraining clock genes, Epitalon may counter the widespread circadian drift of aging, with implications far beyond sleep, touching immunity, metabolism, and neuroprotection