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These sex differences have biological plausibility because GLP-1 receptors are expressed in central appetite circuits and peripheral tissues whose signaling is modulated by estrogen and other sex steroids (Vigil et al., 2022
For example, semaglutide 2.4mg (Wegovy) has demonstrated approximately 15% weight loss at 68 weeks in clinical trials, while liraglutide 3mg (Saxenda) typically achieves around 8% at 56 weeks
Significant reduction in body weight can improve health outcomes and quality of life for many patients
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