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Semaglutide also helps weight loss through other actions that do not depend on making sugar low: It reduces appetite and increases fullness by acting on satiety centres in the brain It slows stomach emptying, so you feel full sooner and longer So, in a non-diabetic person, the body still has normal safety systems, and semaglutide mainly helps by reducing calorie intake, not by forcing sugar down

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[10] extends previous findings to indicate that metformin can be regarded as an enhancer of GLP-1 secretion and possibly as a GLP-1 sensitiser, beyond its known biological functions (Fig