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The sublingual route is a delivery mechanism that gets semaglutide into systemic circulation through mucous membranes, but this does not create the kind of oral fluid residue that saliva drug tests detect, and even if it did, the target antibodies in those tests would not respond to it

Aging (Albany NY) 16 (9), 76837703

Researchers who need to reason about dosing frequency in an experimental model generally rely on the exposure and dosing schedules reported in the specific animal papers rather than on a defined human-style half-life, and route decisions are governed by their study design

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