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In supplement form, it is concentrated and standardised to deliver consistent doses of the active isomers responsible for its metabolic effects
The glycemic improvements were also substantial, with significant reductions in A1c across all dose groups
However, a major limitation of macrophage-reprogramming strategies lies in the extreme plasticity of TAMs and high tumor heterogeneity, which can cause reprogrammed M1 macrophages to revert to an M2 state
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