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Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice

These directions are the core support for translating the hypothesis from theory to application and directly determine whether the gut microbiota-ferroptosis axis mechanism can become a breakthrough framework and intervention target in the study of the gut-joint axis in OA (Figures 2, 3)

The team's working interest was in cytoprotection , the idea (originating with the Hungarian-Canadian endocrinologist Hans Selye and developed for the gut by Andre Robert) that gastric mucosa contains its own defence machinery against acid, alcohol, and stress

Later on, researchers found out that hCG was also a suitable treatment for hypogonadism (low testosterone levels) in men