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Research has confirmed a dual mechanism involving both the pituitary gland and the hypothalamus
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Graphical Abstract The occurrence of TECs ferroptosis in CKD is due to an imbalance in iron and lipid regulation, which drives the occurrence of lipid peroxidation and the accumulation of lipid hydroperoxide
However, after irradiation, GPx1-KO and wild-type mice exhibited almost similar levels of intestinal GPx activity, and this was due to the radiation-induced compensatory upregulation of GPx2 in GPx1-KO mice
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