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No obstante, en modelos experimentales, se plantea que en estadios iniciales de IR existe un aumento de la expresin del GLP-1R, con el objetivo de aumentar la sensibilidad a esta hormona, lo que generara una respuesta adicional del GLP-1 sobre la secrecin de insulina 46 , por lo que esta hormona podra ser participe en la respuesta compensatoria de la CBP 47
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