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injection of 100 nmol kg 1 MK-801 ( n = 8 mice), 100 nmol kg 1 GLP-1 ( n = 8 mice), 100 nmol kg 1 , GLP-1MK-801 ( n = 8 mice), or vehicle (isotonic saline, n = 8 mice) in DIO mice

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Research has observed that GLP-1 receptor agonists may: Improve blood vessel flexibility Reduce oxidative stress Lower systemic inflammation that contributes to plaque formation Support healthier lipid metabolism Some large-scale clinical trials have demonstrated reduced cardiovascular events in patients using GLP therapieseven when weight loss was not the primary variable