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One suggested practice to managing GI AEs is the Three Es method, which comprises 1) education and explanation, 2) escalation to an appropriate dose, and 3) effective management of GI AEs
Among these, compound 2 (Figure 3) demonstrated the strongest inhibitory activity, with an IC 50 value of 6.57 M (94)
UK National Office of Animal Health Compendium of Animal Medicines
An important note: Zepbound has been approved for sleep apnea and Wegovy for cardiovascular risk, with weight loss as a side benefit
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