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The results suggested that sitagliptin has a delayed effect on the progression of carotid atherosclerosis (CAS)
That is not a reason to dismiss treatment
However, at high concentrations, when RNS levels exceed the capability of its detoxification in the biological system, serious damage to cells may occur [147, 148] due to inhibition of mitochondrial respiratory function by competing with O 2 for interaction with cytochrome oxidase [149] and via nitrative/nitrosative stress [150, 151]
Some patients experience constipation due to prolonged transit time, while others may develop diarrhea, possibly related to changes in gut motility patterns or alterations in intestinal fluid handling
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