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Before discontinuing Rybelsus, arrange an appointment with your GP or diabetes care team to discuss: Your reasons for wanting to stop the medication Current diabetes control (recent HbA1c, fasting glucose readings) Alternative treatment options or adjustments to existing medications Monitoring plan for blood glucose levels after discontinuation Dietary and lifestyle strategies to maintain glycaemic control Your healthcare provider may recommend: Alternative medications : Depending on your diabetes control and other health factors, you may need to start or increase doses of other glucose-lowering agents such as metformin, SGLT2 inhibitors, DPP-4 inhibitors, sulfonylureas, or insulin
Follow-up Repeat metabolic markers after 4-12 weeks, with closer review during dose escalation or major appetite changes
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Data availability The single-nucleus RNA-sequencing data (raw FASTQ files and processed count matrices) generated in this study from mouse hippocampus and dorsal vagal complex have been deposited in the ArrayExpress database at EMBL-EBI under accession code E-MTAB-16829
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