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Current mainstay interventions, including intensive lifestyle modification and bariatric surgery, demonstrate suboptimal and often unsustainable long-term efficacy in this genetically defined population, highlighting a critical unmet need for effective, accessible, and durable pharmacological strategies

Members of a dark web drug trafficking ring that sold as many as 11 million counterfeit Xanax pills made in garden sheds and garages in England 's West Midlands were cumulatively sentenced to more than 40 years in prison

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