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Prior to the identification and study of GHK-Cu, research into tissue regeneration and skin remodeling relied primarily on isolated growth factors and nonspecific biochemical agents
A possible role for these cells in myelin repair was considered but quickly ruled out when it was shown that they do not re-enter the cell cycle and proliferate after experimentally induced demyelination and that they do not migrate to the lesion or extend processes to the lesion site (Keirstead and Blakemore, 1997, 1999
Mice were euthanized at 15 weeks of age for analysis
References Thomas, James N., and Victor Fung
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