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Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
The current exploration of new E3 ligases is increasingly guided by computational predictions of their interface interactions with substrates, thus enabling the de novo design of degraders for undruggable targets [43]
For the mechanism, incidence data, and when it peaks, see our companion explainer on Wegovy and Ozempic (semaglutide) constipation
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