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In particular, recent advances in gene therapy, riboflavin transporter biology, and flavoenzyme-targeted pharmacology remain underrepresented in the literature ( Here we focus on studies published from 2012 to 2025 to systematically review the role of riboflavin in neurological diseases by summarizing clinical and preclinical evidence, exploring underlying mechanisms, and highlighting emerging therapeutic strategiesincluding gene-based and combination metabolic therapies

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Regulation of AQP4 in the central nervous system

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