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Allosteric (off active site) activators were reported in the literature as early as the mid-2000s, but they had poor potency, poor pharmacokinetics, species-selective activity (human but not rodent), and none made it close to the clinic

KB: Resources, Writing original draft, Funding acquisition, Methodology, Investigation, Conceptualization, Supervision

The approved pills, sold under the brand name Wegovy, are created by the Danish company Novo Nordisk, which also manufactures the popular diabetes drug Ozempic

It is widely used in pharmaceuticals, nutraceuticals, and cosmetic formulations for its antioxidant, detoxifying, and skin-brightening properties