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Immediate oxygen and glucose deprivation rapidly deplete ATP, disrupt the transmembrane ionic gradients, increase glutamate excitotoxicity, and overload mitochondrial with calcium
In summary, the antimicrobial effect of ELA is mainly related to membrane damage and oxidative stress (Figure 3)
However, the exact mechanisms and long term impacts are still under study
The idea is that taking a smaller amount will make the medication more affordable and lessen side effects but is GLP-1 microdosing effective, or even safe
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