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C., Lage, J
Bisubstrate inhibitors such as NS1, LL320, and II399 based on adenosyl scaffolds have shown promise in this regard 199,200,201
moreover, the heightened proliferation and turnover of leukocytes amplify its depletion, since these cells can concentrate vitamin C up to a hundredfold higher than plasma levels, ultimately leading to a substantial reduction in systemic vitamin C availability during sepsis (Oudemans-van Straaten et al., 2014
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