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Relevant for clinical practice, our findings show that treatment with semaglutide lowered the risk of MACE compared to sitagliptin, while tirzepatide showed at least comparable benefit to dulaglutide, an older GLP-1 receptor agonist with established cardiovascular efficacy

Insurance coverage semaglutide often has broader approval

It means the clinical conversation should include a realistic discussion of adherence, long-term maintenance strategies, and the importance of resistance training as a complementary intervention to preserve and build muscle during pharmacological weight loss

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