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By triggering your pancreas to release insulin, lowering the amount of glucose (sugar) in your blood, and slowing stomach emptying to digest food more slowly, GLP-1 promotes satiety by affecting areas of your brain that process sensations of hunger and fullness
Despite this, GLP-1RA also exert a significant benefit on HF which suggests their use when SGLT-2 inhibitors are contraindicated or not tolerated
These reactions are generally most noticeable in the first hours after administration and tend to become less prominent over successive doses as the body adjusts
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