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This dual mechanism makes it particularly effective for patients whose weight gain is driven by emotional eating, food cravings, or the "reward" component of overeating
excess or altered GIP signalling may contribute to obesity
2 Microdosing involves taking an even lower dosage than this
1DF, half-maximal GEP44 binding at GLP-1R was observed at 113 nM ( versus 5.85 nM for Ex-4), 65.8 nM at Y2-R ( versus 1.51 nM for PYY 3-36 ), and 86.6 nM at Y1-R ( versus 7.9 nM for PYY 1-36 )
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