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1,2 Although not clinically validated or available for widespread use, measurement of holotranscobalamin, the metabolically active form of vitamin B 12 , is an emerging method of detecting deficiency
Standard Dosing Range Most users find therapeutic benefit with daily doses between 0.25mg and 0.5mg
Its use as a research tool should therefore be accompanied by target-confirmation experiments, pathway-specific metabolite monitoring, appropriate vehicle controls, lot-specific documentation, and safety endpoints matched to the study duration and biological model
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