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RCD plays a central role in DKD, overactivated TECs apoptosis causes tubular injury, autophagy deficiency disrupts cellular energy recycling and homeostasis, ferroptosis exacerbates mitochondrial injury via lipid peroxidation and iron overloading, and pyroptosis causes overactivated local cascadic inflammatory response to aggravates renal damage (13, 132, 224)
PMID: 24791752
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Reduced shear stress: a major component in the ability of mammalian tissues to form three-dimensional assemblies in simulated microgravity
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