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Trade-offs in evolutionary immunology: just what is the cost of immunity

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Serious but uncommon side effects of semaglutide include pancreatitis, gallbladder disease (including gallstones and gallbladder inflammation), acute kidney injury, worsening diabetic retinopathy in people with existing eye disease, hypoglycemia when used with insulin or sulfonylureas, and severe allergic reactions such as anaphylaxis or angioedema

Reduced saliva increases the risk of tooth decay, gum disease, oral infections, and difficulty swallowing