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Nissen, who serves as study co-chair of SURMOUNT-MMO, notes that the exclusion of patients with diabetes will avoid confounding of results by favorable outcomes due to tirzepatides antidiabetic effects

Clinical studies demonstrate that individuals with obesity often have blunted GLP-1 secretion in response to meals, creating a vicious cycle of overeating and metabolic dysregulation

Treatment with orforglipron, an oral glucagon like peptide-1 receptor agonist, is associated with improvements of CV risk biomarkers in participants with type 2 diabetes or obesity without diabetes