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Body weight is the one covariate that meaningfully moves semaglutide exposure, and it moves it inversely: a lighter body sees more drug per milligram
This means a doctor must confirm that you need it for a health condition
NAC is generally well-tolerated, but it can interact with certain drugs, especially nitroglycerin and some blood pressure medications
What keeps it directional rather than definitive: different sample sizes (263 vs 338), different dose ranges and escalation schedules, different baseline characteristics, and different statistical estimands and missing-data conventions
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