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The negatives depend on the peptide
Research shows that obesity and depression have a bidirectional relationship
Betul Ibis and colleagues, used the TriNetX database to compare 217,302 diabetes patients on GLP-1 medications with 217,302 matched patients on DPP-4 inhibitors. Patients on GLP-1s had a significantly lower risk of developing rheumatoid arthritis (HR = 0.87, p = 0.026), gout, and osteoarthritis within one year
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