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This effect was abrogated by inhibiting NOSs or guanylate cyclase, implicating NO/cGMP signaling pathway in this process ( Figure 1 )

A dynamic balance is maintained between GSH synthesis, it's recycling from GSSG/oxidized glutathione, and its utilization

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Add anti-inflammatory herbs to your diet : Some root causes of constipation such as high toxins and IBS-C, are associated with increased inflammation in the GI tract, and decreasing this inflammation can be an effective root cause solution for improving constipation