CULLIN-RING ligases (CRLs) are the largest family of E3 ubiquitin ligases in eukaryotes, utilizing CULLIN proteins (CULLIN1, 2, 3, 4 A, 4B, 5, 7, 9) as scaffolds 5
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Collectively, the GLP-1-microbiota-metabolite-gut-brain-muscle network integrates metabolic, inflammatory, and neuroendocrine pathways to support skeletal muscle maintenance, enhance functional strength, and reduce sarcopenia risk, highlighting the potential of GLP-1-based and microbiota-targeted strategies in the management of aging-related and metabolic disorders