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Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism

Reggies/flotillins interact with Rab11a and SNX4 at the tubulovesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking

Furthermore, the well documented efficacy of combined folic acid, B6, and B12-vitamin supplementation to reduce hyperhomocysteinemia could enhance GSH activity and reduce oxidative stress (161)

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